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Chapter 9: Playing the Game / General Rules / Damage / Step 4: If Damage Remains, Reduce the Target's Hit Points

Nonlethal Attacks

Source Core Rulebook pg. 453 2.0
You can make a nonlethal attack in an effort to knock someone out instead of killing them (see Knocked Out and Dying). Weapons with the nonlethal trait (including fists) do this automatically. You take a –2 circumstance penalty to the attack roll when you make a nonlethal attack using a weapon that doesn't have the nonlethal trait. You also take this penalty when making a lethal attack using a nonlethal weapon.

Spells and other effects with the nonlethal trait that reduce a creature to 0 Hit Points knock the creature out instead of killing them.